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The Saints are putting their undefeated Thanksgiving on the line against the Bills in 2021.

By the time the Buffalo Bills and New Orleans Saints kick off on Thanksgiving, millions of turkeys will have been consumed and tryptophan-induced naps will have been taken.

New Orleans Saints vs. Buffalo Bills | NFL Week 12 | 2021 Opponent Profile
Saints vs Bills

The holiday’s third and final game will feature two teams coming off losses. The Saints (5-5) will likely start Trevor Siemian at quarterback for the fourth straight game, even with Taysom Hill receiving a contract extension Monday, and they might be without running back Alvin Kamara again.

The Bills (6-4) have seen their early-season grip on the AFC East slip away and will look to rectify a poor defensive effort that allowed Indianapolis Colts running back Jonathan Taylor to torch them for five touchdowns.

New Orleans made its Thanksgiving debut in 2010. They were the reigning Super Bowl champions at the time when Drew Brees helped lead the team to 30-27 victory over the Jon Kitna-led Cowboys. Since then, they have appeared twice more, beating the Falcons in a home-and-home series during the 2018 and 2019 seasons to achieve a 3-0 record.

Now, the Saints will return to the Superdome on Thanksgiving with the team’s toughest task yet. They must beat the Bills without several key pieces on offense.

New Orleans (5-5) will be starting Trevor Siemian at quarterback, and Siemian has posted an 0-3 record as starter since Jameis Winston’s season-ending ACL tear. Alvin Kamara (knee) and the team’s top two offensive tackles Terron Armstead and Ryan Ramczyk will be out as well. And they’re already without top receiver Michael Thomas.

Can Siemian regain the form he showcased in relief of Winston against the Buccaneers? That will be the Saints’ best hope of competing. But it’s hard to count on that happening against a solid Buffalo defense.

That said, the Bills (6-5) have struggled in recent weeks. They have a 2-3 record in their last five games and were just blown out 41-15 by the Colts. The defense couldn’t contain Jonathan Taylor (five TDs) and quarterback Josh Allen has been inconsistent to date. The defense should bounce back in an easier matchup, but can the Bills’ one-dimensional, pass-heavy offense keep the Saints’ defense guessing enough to win in hostile territory on a short week? That’s not an easy task.

This game looks like the best of the three Thanksgiving matchups overall, and it will go a long way toward determining the potential Wild Card participants in both the AFC and NFC.

Sporting News is tracking live scoring updates and highlights from Bills vs. Saints on Thanksgiving. Follow for complete results from the NFL Week 12 game.

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